Projects beginning in 1999
نویسنده
چکیده
1. To determine if there is an association between peroxisome proliferator activated receptor g (PPARg), agouti-related transcript (ART), neuropeptide Y (NPY) and its receptors NPY, Y5R and Y6R, pro-opiomelanocortin (POMC), uncoupling protein 2 (UCP2), melanocortin-4 receptor (MC4R) and obesity. 2. PCR of microsatellites regions within areas of suspected linkage will be used to identify candidate gene loci using affected sib pairs. 3. Genes showing linkage will be studied for polymorphisms using denaturing gradient gel electrophoresis (DGGE) and sequencing. 4. The prevalence of each polymorphism will be studied in the obese casecontrol population and its association with increased BMI and CHD determined.
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